Steven Evans, Beth Israel Medical Center; Elizabeth Cherry and Harold
Hastings, Hofstra University;
Isabelle Banville and Richard Gray, University of Alabama.
Scroll waves of electrical activity in mammalian cardiac tissue have
become a major focus of research because of their
central role in arrhythmogenesis. We simulate the effects of two electromechanical-uncoupling
drugs (DAM and CytoD) on
the dynamics of sprial waves in ventricles using an existing 3D rabbit
ventricular anatomical structure along with an
ionic cell model based on experimentally measured mesoscopic electrophysiological
properties of rabbit cells. As in
experiments, we found that the use of DAM resulted mostly in stable
tachycardia (single scroll waves) with a period of
about 135 ms, while with CytoD more complex fibrillatory states were
observed (multiple scroll waves). The difference in
behavior between these two drugs can be explained in terms of the interaction
between the ventricular structure and the
electrical cell dynamics.